Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial
نویسندگان
چکیده
Determine the effect of French Maritime Pine Bark Extract (PBE; Pycnogenol®) on Attention-Deficit Hyperactivity Disorder (ADHD) behaviour and co-morbid physical/psychiatric symptoms, compared to placebo medicine MPH, assess its tolerability. Behaviour (measured by ADHD-Rating Scale (ADHD-RS) Social-Emotional Questionnaire (SEQ)) physical complaints were evaluated in weeks 5 10. Eighty-eight paediatric ADHD patients (70 % male, mean age 10.1 years) randomised (n = 30), PBE 32) or MPH 26). Teachers reported significant improvement total hyperactivity/impulsivity ADHD-RS scores after 10 placebo. also improved inattention. SEQ ratings support results. Adverse effects five times more frequently for than PBE. appears a good alternative especially primary school environment, fortiori when considering almost complete lack adverse effects.
منابع مشابه
Pycnogenol , French Maritime Pine Bark Extract
Pycnogenol is the registered trade name for a special standardized extract from the bark of the French maritime pine (Pinus pinaster ssp. atlantica), distributed by Horphag Research, U.K. The spray-dried, powdered extract is marketed worldwide as a food supplement, a herbal medicine, an ingredient in cosmetics, and as a food additive. The traditional use of pine bark was in the treatment of scu...
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ژورنال
عنوان ژورنال: Journal of Functional Foods
سال: 2022
ISSN: ['2214-9414', '1756-4646']
DOI: https://doi.org/10.1016/j.jff.2022.105246